Koisio Technology-Produced Water Significantly Decreased Inflammation and Multiple Injuries in Mouse Model of Dextran Sulfate Sodium Salt-Induced Acute Colon Inflammation

分类： 生物学 >> 生物学其他学科 提交时间： 2022-12-04

Ying, Weihai Men, Yinghui Zhang, Mingchao Zhang, Youjun

摘要： Inflammation is one of the crucial pathological factors of numerous diseases. It is critical to search for new strategies to decrease inflammation-produced damage. Our previous study has reported that Koisio technology-produced cell culture media produced increased antioxidant capacity of cell cultures. Since oxidative stress plays a significant role in inflammation-produced tissue injury, in our current study we used a mouse model of acute colon inflammation to test our hypothesis that Koisio technology-produced water may decrease inflammation-produced tissue damage. Our study has obtained evidence supporting the hypothesis: First, Koisio technology-produced water significantly attenuated inflammation-induced shortening of colon length in the mouse model of Dextran Sulfate Sodium salt (DSS)-induced acute colon inflammation; second, Koisio technology-produced water significantly attenuated colon inflammation-induced increase in DAI in the mouse model; third, Koisio technology-produced water significantly attenuated colon inflammation-induced increase in the Spleen Index in the mouse model; and fourth, Koisio technology-produced water significantly attenuated the increases in the myeloperoxidase (MPO) activity and the Eosinophil peroxidase (EPO) activity in the mouse model. Collectively, our study has provided novel evidence suggesting that Koisio technology-produced water can decrease inflammation-induced tissue damage in the mouse model of acute colon inflammation.

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